The relative proportion of codeine to morphine, the commonest opium alkaloid at 4% to 23%, has a tendency to be relatively bigger inside the poppy straw means of making ready opium alkaloids.
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Codeine coupled with an antihistamine, and often caffeine, is offered below a variety of trade names and is available with no prescription. These merchandise are held at the rear of the counter and need to be dispensed by a pharmacist who could Restrict quantities.[citation necessary]
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This drug is assessed as a pregnancy Category C drug. There isn't any sufficient and properly-managed studies finished in pregnant Women of all ages. Codeine should only be employed during pregnancy In case the opportunity profit outweighs the potential danger in the drug on the fetus Label. Codeine has revealed embryolethal and fetotoxic outcomes while in the hamster, rat together with mouse styles at about 2-4 times the maximum advised human dose Label.
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Just like other opioids, a most likely really serious adverse drug reaction is respiratory depression. This despair is dose-similar and is a system for the doubtless lethal repercussions of overdose.
The UAE normally takes an exceptionally stringent line on medicines, with several frequent medication, notably everything containing codeine being banned Until one particular includes a notarized and authenticated physician's prescription.